Cocaine: On-line analysis of an accumbens amine neural basis for psychomotor behavior
Identifieur interne : 001422 ( Main/Exploration ); précédent : 001421; suivant : 001423Cocaine: On-line analysis of an accumbens amine neural basis for psychomotor behavior
Auteurs : Patricia A. Broderick [États-Unis]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1991.
English descriptors
- Teeft :
- Accumbens, Accumbens amine, Accumbens synaptic concentrations, Activity pattern analysis, Ambulation, Amine, Animal control values, Anova, Anova statistics, Basal, Basal synaptic concentrations, Baseline, Baseline values, Behavioral parameters, Biogenic amines, Body temperature, Brain tissue, Broderick, Broderick table, Central ambulations, Cocaine, Cocaine injection, Cocaine lsthour, Cocaine reinforcement, Cocaine treatment modalities, Confidence limits, Confidence limits statistics, Control values, Detection limit, Dopamine, Dopaminergic, Dopaminergic hypothesis, Electrical ground, Electrochemical, Electrochemical signal, Electrode, Electrode paste mixture, Electrophysiological effects, Experimental studies, Extracellular dopamine, Fine movements, Fresh deoxygenated phosphate buffer solution, Locomotor activity, Medwire corp, Minigard surge suppressor, Neuron, Nucleus accumbens, Peak area, Peak areas, Peak height, Pharmacol, Physiological saline, Psychomotor, Psychomotor behavior, Psychomotor stimulant activity, Psychomotor stimulant behavior, Psychomotor stimulation, Reference electrode, Reinforcement, Results section, Same oxidation, Serotonin, Significant increase, Silver wire, Stainless steel, Stimulant, Subcutaneous cocaine, Synaptic, Synaptic concentrations, Time course ambulations, Time course effect, Time course studies, Vivo, Vivo synaptic concentrations, Vivo voltammetric studies, Vivo voltammetry.
Abstract
Abstract: Dose-response studies on subcutaneous cocaine were done to ascertain its effects in nucleus accumbens in dopaminergic and serotonergic neuronal circuitry in the behaving rat with in vivo voltammetry. Simultaneously, and at each dose of cocaine, unconditioned psychomotor stimulant behavior induced by cocaine was studied in terms of multiple concurrent measures of spontaneous behavior and by activity patterns of locomotion. Time course studies showed that the neurochemical effects of cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.001) increased accumbens synaptic concentrations of dopamine (DA) and concurrently and significantly (p<0.0001) decreased accumbens synaptic concentrations of serotonin (5-HT) in a dose response manner. Simulataneous behavioral time course studies showed that cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.0001) increased ambulations (locomotor activity), fine movements (stereotypic movements of sniffing and grooming) and rearing behavior, while significantly decreasing agoraphobic behavior, as measured by a statistically significant increase in central ambulations (p<0.0001). The high dose of cocaine (40 mg/kg SC) significantly increased fine movements over those produced by the lower doses of cocaine (p<0.0002). One import of the findings is that the DA and 5-HT biogenic amine response occurs in a behavioral paradigm of psychomotor stimulation, which is a known measure of reinforcement. Another is that the biogenic amines DA and 5-HT are affected by cocaine in this reinforcement paradigm with exactly opposite directionality. Finally, acute cocaine administration is shown to produce a dose response inhibition of agoraphobia (fear),w hich is highly correlated (ϱ=.983, p<0.01) with the opposing effects of cocaine on the accumbens biogenic amines, DA and 5-HT.
Url:
DOI: 10.1016/0091-3057(91)90112-F
Affiliations:
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Broderick</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Room J-910, The City University of New York Medical School</wicri:regionArea><wicri:noRegion>The City University of New York Medical School</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Biology and Psychology, CUNY Graduate School. Convent Ave. and W. 138th St., New York, NY 10031</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">40</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="959">959</biblScope><biblScope unit="page" to="968">968</biblScope></imprint><idno type="ISSN">0091-3057</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Accumbens</term><term>Accumbens amine</term><term>Accumbens synaptic concentrations</term><term>Activity pattern analysis</term><term>Ambulation</term><term>Amine</term><term>Animal control values</term><term>Anova</term><term>Anova statistics</term><term>Basal</term><term>Basal synaptic concentrations</term><term>Baseline</term><term>Baseline values</term><term>Behavioral parameters</term><term>Biogenic amines</term><term>Body temperature</term><term>Brain tissue</term><term>Broderick</term><term>Broderick table</term><term>Central ambulations</term><term>Cocaine</term><term>Cocaine injection</term><term>Cocaine lsthour</term><term>Cocaine reinforcement</term><term>Cocaine treatment modalities</term><term>Confidence limits</term><term>Confidence limits statistics</term><term>Control values</term><term>Detection limit</term><term>Dopamine</term><term>Dopaminergic</term><term>Dopaminergic hypothesis</term><term>Electrical ground</term><term>Electrochemical</term><term>Electrochemical signal</term><term>Electrode</term><term>Electrode paste mixture</term><term>Electrophysiological effects</term><term>Experimental studies</term><term>Extracellular dopamine</term><term>Fine movements</term><term>Fresh deoxygenated phosphate buffer solution</term><term>Locomotor activity</term><term>Medwire corp</term><term>Minigard surge suppressor</term><term>Neuron</term><term>Nucleus accumbens</term><term>Peak area</term><term>Peak areas</term><term>Peak height</term><term>Pharmacol</term><term>Physiological saline</term><term>Psychomotor</term><term>Psychomotor behavior</term><term>Psychomotor stimulant activity</term><term>Psychomotor stimulant behavior</term><term>Psychomotor stimulation</term><term>Reference electrode</term><term>Reinforcement</term><term>Results section</term><term>Same oxidation</term><term>Serotonin</term><term>Significant increase</term><term>Silver wire</term><term>Stainless steel</term><term>Stimulant</term><term>Subcutaneous cocaine</term><term>Synaptic</term><term>Synaptic concentrations</term><term>Time course ambulations</term><term>Time course effect</term><term>Time course studies</term><term>Vivo</term><term>Vivo synaptic concentrations</term><term>Vivo voltammetric studies</term><term>Vivo voltammetry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dose-response studies on subcutaneous cocaine were done to ascertain its effects in nucleus accumbens in dopaminergic and serotonergic neuronal circuitry in the behaving rat with in vivo voltammetry. Simultaneously, and at each dose of cocaine, unconditioned psychomotor stimulant behavior induced by cocaine was studied in terms of multiple concurrent measures of spontaneous behavior and by activity patterns of locomotion. Time course studies showed that the neurochemical effects of cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.001) increased accumbens synaptic concentrations of dopamine (DA) and concurrently and significantly (p<0.0001) decreased accumbens synaptic concentrations of serotonin (5-HT) in a dose response manner. Simulataneous behavioral time course studies showed that cocaine (10, 20, and 40 mg/kg SC) significantly (p<0.0001) increased ambulations (locomotor activity), fine movements (stereotypic movements of sniffing and grooming) and rearing behavior, while significantly decreasing agoraphobic behavior, as measured by a statistically significant increase in central ambulations (p<0.0001). The high dose of cocaine (40 mg/kg SC) significantly increased fine movements over those produced by the lower doses of cocaine (p<0.0002). One import of the findings is that the DA and 5-HT biogenic amine response occurs in a behavioral paradigm of psychomotor stimulation, which is a known measure of reinforcement. Another is that the biogenic amines DA and 5-HT are affected by cocaine in this reinforcement paradigm with exactly opposite directionality. Finally, acute cocaine administration is shown to produce a dose response inhibition of agoraphobia (fear),w hich is highly correlated (ϱ=.983, p<0.01) with the opposing effects of cocaine on the accumbens biogenic amines, DA and 5-HT.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></noRegion><name sortKey="Broderick, Patricia A" sort="Broderick, Patricia A" uniqKey="Broderick P" first="Patricia A." last="Broderick">Patricia A. Broderick</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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